CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications

Cancer Conundrum

The main event is when physiologic EMT is seen in gastrulation; formation and migration of neural crest cells.[3] The progression of EMT is further classified into primary (1°), secondary (2°) and tertiary (3°) EMT,[2] depending on the number or sequential sweeps of EMT and mesenchymal‐epithelial transition (MET).[2] MET signifies the conversion of the mesenchymal phenotype back into the epithe...

Infant Crying: A Clinical Conundrum

Crying is a common, normal occurrence in a healthy infant. However, crying is one of the primary reasons parents seek health care for their infant child (Barr, 199 Many parents find inconsolable crying to be particularly difficult because the use of soothing techniques to comfort the infant seems futile. Parents also may view infant crying as a negative reflection on their ability to parent, in...

Molecular Pathways Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

Hyaluronan is a prominent component of the micro-environment in most malignant

Are intellectual property rights hampering cancer research?

Cancer Stem Cell Markers CD44, CD133 in Primary Gastric Adenocarcinoma

Cancer stem cells (CSCs) are unique subpopulations that have the capacity to drive malignant progression with renewal abilities. Recently the role of some of CSCs in gastric adenocarcinoma has been studied. This study was performed in order to evaluate CD44 and CD133 expressions by immunohistochemistry in 95 primary gastric adenocarcinoma and their relation to clinical and pathological paramete...